Our unique accelerated technology platform, iBioLaunch™, has the potential to revolutionize the manufacture of biopharmaceuticals.

The iBioLaunch™ platform was developed to rapidly produce high levels of target protein:

• A “launch vector” is constructed of a cDNA sequence that encodes the target protein cloned into a plant viral gene expression vector.
• The launch vectors are introduced into agrobacteria where they multiply to very large copy numbers.
• The agrobacteria, carrying their payload of launch vectors, are introduced into all aerial parts of green plants by vacuum infiltration. This process provides for near complete leaf coverage, increasing the efficiency and speed of protein production.
• Once the plants have been infiltrated with agrobacteria, the viral sequences of the launch vectors along with the cloned target sequences are massively amplified through virus replication. Translation of these recombinant viral vector mRNAs results in accumulation of hundred milligram quantities of target protein per kilogram of fresh plant tissue in less than a week.
• The plants accumulate these high levels of target protein in their leaf and stem tissue. This is termed transient expression because the target gene sequence is not incorporated into the plant chromosome and thus does not result in the creation of transgenic plants.
• The plant biomass is harvested, ground and clarified to produce an extract containing the protein of interest. Proteins are further purified as required using well-established separation and chromatography steps.